Bladder cancer is the fifth most common neoplasm and the twelfth leading cause of cancer death.
Males are affected three times more frequently than women.Numerous chemicals are suspected bladder cancer forming agents, however, only cigarette smoking and occupational exposure to a certain class of organic chemicals called aromatic amines are well-established risk factors. At diagnosis about 75% of patients have superficial bladder cancer and 25% have invasive or metastatic disease. Although superficial bladder tumors tend to recur frequently, most of recurrent tumors stay in the superficial areas. However, 5-30% of superficial tumors progress to invasive disease.

Invasive tumors have a higher risk to metastasize. For untreated metastatic disease, the 2-year survival rate is less than 5%.
There are many treatment options for bladder cancer patients, some have long been in use, some are still considered experimental. Each case is unique, and there are many factors to consider before deciding which approach is best for the individual. But unfortunately a cure has remained elusive for many people. Since none of the approaches is offering a guarantee of cure.

The Bladder

The bladder is a hollow organ in the lower abdomen. It stores urine, the liquid waste produced by the kidneys. Urine passes from each kidney into the bladder through a tube called a ureter.

An outer layer of muscle surrounds the inner lining of the bladder. When the bladder is full, the muscles in the bladder wall can tighten to allow urination. Urine leaves the bladder through another tube, the urethra.

Understanding Cancer

Cancer is a group of many related diseases. All cancers begin in cells,
the body's basic unit of life. Cells make up tissues, and tissues make up the organs of the body.

Normally, cells grow and divide to form new cells as the body needs
them. When cells grow old and die, new cells take their place.

Sometimes this orderly process goes wrong. New cells form when the body does not need them, and old cells do not die when they should. These extra cells can form a mass of tissue called a growth or tumor.

Tumors can be benign or malignant:

Benign tumors are not cancer. Usually, doctors can remove them. Cells from benign tumors do not spread to other parts of the body. In most cases, benign tumors do not come back after they are removed. Most important, benign tumors are rarely a threat to life.

Malignant tumors are cancer. They are generally more serious. Cancer
cells can invade and damage nearby tissues and organs. Also, cancer cells can break away from a malignant tumor and enter the bloodstream or the lymphatic system. That is how cancer cells spread from the original (primary) tumor to form new tumors in other organs. The spread of cancer is called metastasis.

The wall of the bladder is lined with cells called transitional cells and squamous cells. More than 90 percent of bladder cancers begin in the
transitional cells. This type of bladder cancer is called transitional cell
carcinoma. About 8 percent of bladder cancer patients have squamous cell carcinomas.

Cancer that is only in cells in the lining of the bladder is called superficial bladder cancer. The doctor might call it carcinoma in situ.
This type of bladder cancer often comes back after treatment. If this
happens, the disease most often recurs as another superficial cancer in the bladder.

Cancer that begins as a superficial tumor may grow through the lining
and into the muscular wall of the bladder. This is known as invasive
cancer. Invasive cancer may extend through the bladder wall. It may grow into a nearby organ such as the uterus or vagina (in women) or the prostate gland (in men). It also may invade the wall of the abdomen.

When bladder cancer spreads outside the bladder, cancer cells are often found in nearby lymph nodes. If the cancer has reached these nodes, cancer cells may have spread to other lymph nodes or other organs, such as the lungs, liver, or bones.

When cancer spreads (metastasizes) from its original place to another
part of the body, the new tumor has the same kind of abnormal cells and the same name as the primary tumor. For example, if bladder cancer spreads to the lungs, the cancer cells in the lungs are actually bladder cancer cells.
The disease is metastatic bladder cancer, not lung cancer. It is treated as bladder cancer, not as lung cancer. Doctors sometimes call the new tumor "distant" disease.

Bladder Cancer: Who's at Risk?

No one knows the exact causes of bladder cancer. However, it is clear that this disease is not contagious. No one can "catch" cancer from another person.

People who get bladder cancer are more likely than other people to have certain risk factors. A risk factor is something that increases a person's chance of developing the disease.

Still, most people with known risk factors do not get bladder cancer, and many who do get this disease have none of these factors. Doctors can seldom explain why one person gets this cancer and another does not.

Studies have found the following risk factors for bladder cancer:

Age. The chance of getting bladder cancer goes up as people get older. People under 40 rarely get this disease.

Tobacco. The use of tobacco is a major risk factor. Cigarette smokers
are two to three times more likely than nonsmokers to get bladder cancer. Pipe and cigar smokers are also at increased risk.

Occupation. Some workers have a higher risk of getting bladder cancer because of carcinogens in the workplace. Workers in the rubber, chemical, and leather industries are at risk. So are hairdressers, machinists, metal workers, printers, painters, textile workers, and truck drivers.

Infections. Being infected with certain parasites increases the risk of
bladder cancer. These parasites are common in tropical areas but not in the United States.

Treatment with cyclophosphamide or arsenic. These drugs are used to
treat cancer and some other conditions. They raise the risk of bladder cancer.

Race. Whites get bladder cancer twice as often as African Americans and Hispanics. The lowest rates are among Asians. Being a man. Men are two to three times more likely than women to get bladder cancer.

Family history. People with family members who have bladder cancer are more likely to get the disease. Researchers are studying changes in certain genes that may increase the risk of bladder cancer.

Personal history of bladder cancer. People who have had bladder cancer have an increased chance of getting the disease again.

Chlorine is added to water to make it safe to drink. It kills deadly bacteria. However, chlorine by-products sometimes can form in chlorinated water. Researchers have been studying chlorine by-products for more than 25 years. So far, there is no proof that chlorinated water causes bladder cancer in people. Studies continue to look at this question.

Some studies have found that saccharin, an artificial sweetener, causes bladder cancer in animals. However, research does not show that saccharin causes cancer in people.

People who think they may be at risk for bladder cancer should discuss this concern with their doctor. The doctor may suggest ways to reduce the risk and can plan an appropriate schedule for checkups.

Recognizing Symptoms

Common symptoms of bladder cancer include: Blood in the urine (making the urine slightly rusty to deep red),Pain during urination, andFrequent urination, or feeling the need to urinate without results. These symptoms are not sure signs of bladder cancer. Infections, benign tumors, bladder stones, or other problems also can cause these symptoms.
Anyone with these symptoms should see a doctor so that the doctor can diagnose and treat any problem as early as possible. People with
symptoms like these may see their family doctor or a urologist, a doctor who specializes in diseases of the urinary system.

Diagnosis

If a patient has symptoms that suggest bladder cancer, the doctor may check general signs of health and may order lab tests. The person may have one or more of the following procedures:

Physical exam -- The doctor feels the abdomen and pelvis for tumors.
The physical exam may include a rectal or vaginal exam.

Urine tests -- The laboratory checks the urine for blood, cancer cells, and other signs of disease.

Intravenous pyelogram -- The doctor injects dye into a blood vessel.
The dye collects in the urine, making the bladder show up on x-rays.

Cystoscopy -- The doctor uses a thin, lighted tube (cystoscope) to look directly into the bladder. The doctor inserts the cystoscope into the bladder through the urethra to examine the lining of the bladder. The patient may need anesthesia for this procedure.

The doctor can remove samples of tissue with the cystoscope. A pathologist then examines the tissue under a microscope. The removal of tissue to look for cancer cells is called a biopsy. In many cases, a biopsy is the only sure way to tell whether cancer is present. For a small number of patients, the doctor removes the entire cancerous area during the biopsy. For these patients, bladder cancer is diagnosed and treated in a single procedure.

Staging

If bladder cancer is diagnosed, the doctor needs to know the stage, or extent, of the disease to plan the best treatment. Staging is a careful attempt to find out whether the cancer has invaded the bladder wall, whether the disease has spread, and if so, to what parts of the body.

The doctor may determine the stage of bladder cancer at the time of
diagnosis, or may need to give the patient more tests. Such tests may include imaging tests -- CT scan, magnetic resonance imaging (MRI), sonogram, intravenous pyelogram, bone scan, or chest x-ray. Sometimes staging is not complete until the patient has surgery.

These are the main features of each stage of the disease:

Stage 0 -- The cancer cells are found only on the surface of the inner lining of the bladder. The doctor may call this superficial cancer or carcinoma in situ.

Stage I -- The cancer cells are found deep in the inner lining of the
bladder. They have not spread to the muscle of the bladder.

Stage II -- The cancer cells have spread to the muscle of the bladder.

Stage III -- The cancer cells have spread through the muscular wall of the bladder to the layer of tissue surrounding the bladder. The cancer cells may have spread to the prostate (in men) or to the uterus or vagina (in women).

Stage IV -- The cancer extends to the wall of the abdomen or to the
wall of the pelvis. The cancer cells may have spread to lymph nodes and other parts of the body far away from the bladder, such as the lungs.

Treatment for Bladder Cancer

People with bladder cancer have many treatment options. They may have surgery, radiation therapy, chemotherapy, or biological therapy. Some patients get a combination of therapies.

The doctor is the best person to describe treatment choices and discuss the expected results of treatment.

A patient may want to talk to the doctor about taking part in a clinical trial, a research study of new treatment methods. Clinical trials are an important option for people with all stages of bladder cancer.

Surgery is a common treatment for bladder cancer. The type of surgery depends largely on the stage and grade of the tumor. The doctor can explain each type of surgery and discuss which is most suitable for the patient:

Transurethral resection: The doctor may treat early (superficial) bladder cancer with transurethral resection (TUR). During TUR, the doctor inserts a cystoscope into the bladder through the urethra. The doctor then uses a tool with a small wire loop on the end to remove the cancer and to burn away any remaining cancer cells with an electric current. (This is called fulguration.) The patient may need to be in the hospital and may need anesthesia. After TUR, patients may also have chemotherapy or biological therapy.

Radical cystectomy: For invasive bladder cancer, the most common type of surgery is radical cystectomy. The doctor also chooses this type of surgery when superficial cancer involves a large part of the bladder. Radical cystectomy is the removal of the entire bladder, the nearby lymph nodes, part of the urethra, and the nearby organs that may contain cancer cells. In men, the nearby organs that are removed are the prostate, seminal vesicles, and part of the vas deferens. In women, the uterus, ovaries, fallopian tubes, and part of the vagina are removed.

Segmental cystectomy: In some cases, the doctor may remove only part of the bladder in a procedure called segmental cystectomy. The doctor chooses this type of surgery when a patient has a low-grade cancer that has invaded the bladder wall in just one area.

Sometimes, when the cancer has spread outside the bladder and cannot be completely removed, the surgeon removes the bladder but does not try to get rid of all the cancer. Or, the surgeon does not remove the bladder but makes another way for urine to leave the body. The goal of the surgery may be to relieve urinary blockage or other symptoms caused by the cancer.

When the entire bladder is removed, the surgeon makes another way to collect urine. The patient may wear a bag outside the body, or the
surgeon may create a pouch inside the body with part of the intestine.

Radiation therapy (also called radiotherapy) uses high-energy rays to
kill cancer cells. Like surgery, radiation therapy is local therapy. It affects cancer cells only in the treated area.

A small number of patients may have radiation therapy before surgery to shrink the tumor. Others may have it after surgery to kill cancer cells that may remain in the area. Sometimes, patients who cannot have surgery have radiation therapy instead.

Doctors use two types of radiation therapy to treat bladder cancer:

External radiation: A large machine outside the body aims radiation at
the tumor area. Most people receiving external radiation are treated 5 days a week for 5 to 7 weeks as an outpatient. This schedule helps protect healthy cells and tissues by spreading out the total dose of radiation.
Treatment may be shorter when external radiation is given along with radiation implants.

Internal radiation: The doctor places a small container of a radioactive substance into the bladder through the urethra or through an incision in the abdomen. The patient stays in the hospital for several days during this treatment. To protect others from radiation exposure, patients may not be able to have visitors or may have visitors for only a short period of time while the implant is in place. Once the implant is removed, no radioactivity is left in the body.

Some patients with bladder cancer receive both kinds of radiation therapy Chemotherapy uses drugs to kill cancer cells. The doctor may use one drug or a combination of drugs.

For patients with superficial bladder cancer, the doctor may use intravesical chemotherapy after removing the cancer with TUR. This is
local therapy. The doctor inserts a tube (catheter) through the urethra and puts liquid drugs in the bladder through the catheter. The drugs remain in the bladder for several hours. They mainly affect the cells in the bladder.
Usually, the patient has this treatment once a week for several weeks.
Sometimes, the treatments continue once or several times a month for up to a year.

If the cancer has deeply invaded the bladder or spread to lymph nodes or other organs, the doctor may give drugs through a vein. This treatment is called intravenous chemotherapy. It is systemic therapy, meaning that the drugs flow through the bloodstream to nearly every part of the body.
The drugs are usually given in cycles so that a recovery period follows
every treatment period.

The patient may have chemotherapy alone or combined with surgery,
radiation therapy, or both. Usually chemotherapy is an outpatient treatment given at the hospital, clinic, or at the doctor's office. However, depending on which drugs are given and the patient's general health, the patient may need a short hospital stay.

Biological therapy (also called immunotherapy) uses the body's natural
ability (immune system) to fight cancer. Biological therapy is most often used after TUR for superficial bladder cancer. This helps prevent the cancer from coming back.

The doctor may use intravesical biological therapy with BCG solution.
BCG solution contains live, weakened bacteria. The bacteria stimulate the immune system to kill cancer cells in the bladder. The doctor uses a catheter to put the solution in the bladder. The patient must hold the solution in the bladder for about 2 hours. BCG treatment is usually
done once a week for 6 weeks.

Side Effects of Cancer Treatment

Because cancer treatment may damage healthy cells and tissues, unwanted side effects sometimes occur. These side effects depend on many factors, including the type and extent of the treatment. Side effects may not be the same for each person, and they may even change from one treatment session to the next. Doctors and nurses will explain the possible side effects of treatment and how they will help the patient manage them.

Surgery

For a few days after TUR, patients may have some blood in their urine
and difficulty or pain when urinating. Otherwise, TUR generally causes few problems.

After cystectomy, most patients are uncomfortable during the first few days. However, medicine can control the pain. Patients should feel free to discuss pain relief with the doctor or nurse. Also, it is common to feel tired or weak for a while. The length of time it takes to recover from an operation varies for each person.

After segmental cystectomy, patients may not be able to hold as much urine in their bladder as they used to, and they may need to urinate more often.
In most cases, this problem is temporary, but some patients may have
long-lasting changes in how much urine they can hold.

If the surgeon removes the bladder, the patient needs a new way to store and pass urine. In one common method, the surgeon uses a piece of the person's small intestine to form a new tube through which urine can pass.
The surgeon attaches one end of the tube to the ureters and connects the other end to a new opening in the wall of the abdomen. This opening is called a stoma. A flat bag fits over the stoma to collect urine, and a special adhesive holds it in place. The operation to create the stoma is called a urostomy or an ostomy.

For some patients, the doctor is able to use a part of the small intestine to make a storage pouch (called a continent reservoir) inside the body.
Urine collects in the pouch instead of going into a bag. The surgeon connects the pouch to the urethra or to a stoma. If the surgeon connects the pouch to a stoma, the patient uses a catheter to drain the urine.

Bladder cancer surgery may affect a person's sexual function. Because the surgeon removes the uterus and ovaries in a radical cystectomy, women are not able to get pregnant. Also, menopause occurs at once. Hot flashes and other symptoms of menopause caused by surgery may be more severe than those caused by natural menopause. Many women take hormone replacement therapy (HRT) to relieve these problems. If the surgeon removes part of the vagina during a radical cystectomy, sexual intercourse may be difficult.

In the past, nearly all men were impotent after radical cystectomy, but improvements in surgery have made it possible for some men to avoid this problem. Men who have had their prostate gland and seminal vesicles removed no longer produce semen, so they have dry orgasms. Men who wish to father children may consider sperm banking before surgery or sperm retrieval later on.

It is natural for a patient to worry about the effects of bladder cancer surgery on sexuality. Patients may want to talk with the doctor about possible side effects and how long these side effects are likely to last.
Whatever the outlook, it may be helpful for patients and their partners
to talk about their feelings and help one another find ways to share intimacy during and after treatment.

Radiation Therapy

The side effects of radiation therapy depend mainly on the treatment
dose and the part of the body that is treated. Patients are likely to become very tired during radiation therapy, especially in the later weeks of treatment. Resting is important, but doctors usually advise patients to try to stay as active as they can.

External radiation may permanently darken or "bronze" the skin in the
treated area. Patients commonly lose hair in the treated area and their skin may become red, dry, tender, and itchy. These problems are
temporary, and the doctor can suggest ways to relieve them.

Radiation therapy to the abdomen may cause nausea, vomiting, diarrhea, or urinary discomfort. The doctor can suggest medicines to ease these problems.

Radiation therapy also may cause a decrease in the number of white blood cells, cells that help protect the body against infection. If the blood counts are low, the doctor or nurse may suggest ways to avoid getting an infection. Also, the patient may not get more radiation therapy until blood counts improve. The doctor will check the patient's blood counts regularly and change the treatment schedule if it is necessary.

For both men and women, radiation treatment for bladder cancer can
affect sexuality. Women may experience vaginal dryness, and men may have difficulty with erections.

Although the side effects of radiation therapy can be distressing, the
doctor can usually treat or control them. It also helps to know that,
in most cases, side effects are not permanent.

Chemotherapy

The side effects of chemotherapy depend mainly on the drugs and the
doses the patient receives as well as how the drugs are given. In addition, as with other types of treatment, side effects vary from patient to patient.

Anticancer drugs that are placed in the bladder cause irritation, with
some discomfort or bleeding that lasts for a few days after treatment. Some drugs may cause a rash when they come into contact with the skin or genitals.

Systemic chemotherapy affects rapidly dividing cells throughout the
body, including blood cells. Blood cells fight infection, help the blood to clot, and carry oxygen to all parts of the body. When anticancer drugs damage blood cells, patients are more likely to get infections, may bruise or bleed easily, and may have less energy. Cells in hair roots and cells that line the digestive tract also divide rapidly. As a result, patients may lose their hair and may have other side effects such as poor appetite, nausea and vomiting, or mouth sores. Usually, these side effects go away gradually during the recovery periods between treatments or after treatment is over.

Certain drugs used in the treatment of bladder cancer also may cause
kidney damage. To protect the kidneys, patients need a lot of fluid. The nurse may give the patient fluids by vein before and after treatment. Also, the patient may need to drink a lot of fluids during treatment with these drugs.

Certain anticancer drugs can also cause tingling in the fingers, ringingin the ears, or hearing loss. These problems may go away after treatment stops.

Biological Therapy

BCG therapy can irritate the bladder. Patients may feel an urgent need to urinate, and may need to urinate frequently. Patients also may have pain, especially when urinating. They may feel tired. Some patients may have blood in their urine, nausea, a low-grade fever, or chills.

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